High-Dose Platelet-Rich Plasma (PRP) Injections Show Long-Term Relief for Knee Osteoarthritis, Study Finds

If you’re one of the millions suffering with chronic knee pain from osteoarthritis (OA), there’s good news: a new study published in Scientific Reports has shown that high-dose PRP injections—specifically those containing 10 billion platelets—offer superior and longer-lasting relief compared to standard treatments like hyaluronic acid (HA) injections.

At Orthohealing Center, we specialize in cutting-edge, evidence-based regenerative medicine. This new research further supports what we’ve long seen in our clinical experience: when it comes to PRP, the dose matters.
What Is PRP, and How Can It Help Knee Osteoarthritis?

Platelet-Rich Plasma (PRP) is an advanced treatment that uses a concentration of your own blood platelets to accelerate healing and reduce inflammation in damaged tissues—like the cartilage and synovium in an osteoarthritic knee.
PRP contains powerful growth factors and anti-inflammatory proteins that can:

• Decrease joint pain and stiffness
• Improve mobility and function
• Support cartilage health and slow degeneration
• Reduce the need for pain medications or surgery

However, not all PRP is created equal. The concentration of platelets and the way the PRP is prepared can significantly impact outcomes.

New Research: High-Dose PRP Works Better and Lasts Longer than standard PRP (read the research article here)

In this randomized controlled trial, 150 patients with moderate knee OA were treated with either:

• High-dose PRP (10 billion platelets) prepared using a new, high-yield technique

~ or ~

• A standard hyaluronic acid (HA) injection, a common lubricant-type injection

The patients were monitored over the course of one year, and the results were striking:
Key Findings:
✅ Patients who received PRP injections experienced more pain relief and improved knee function compared to the HA group
✅ Improvements in walking distance (+120 meters) and reduction in inflammatory markers (IL-6, TNF-α) were seen as early as one month after injection
✅ These benefits were sustained for up to 12 months, indicating a long-term chondroprotective effect (protection of joint cartilage)

Why Dose Matters in PRP Therapy
While PRP is widely available, the concentration of platelets in the final injection can vary greatly between clinics, often due to inconsistent preparation methods. Some lower-quality kits or manual techniques only produce 1 – 2 times the baseline platelet count, leading to mixed or short-lived results or requiring frequent injection series to achieve the optimal dose.

This new study addressed that problem by creating a high-yield, cost-effective PRP method using a specialized 1-micron filtration step. The process achieved 90% platelet recovery and zero white blood cells, resulting in a pure, high-concentration product with over 10 billion platelets in just 8ml of PRP.

Leading to the best outcomes, this optimal dose is what the Orthohealing Center strives for.

How Orthohealing Center Is Leading the Way in PRP for Knee Osteoarthritis

Our regenerative medicine orthopedic specialists have pioneered advanced PRP protocols for nearly 2 decades, using:

• Customized PRP formulations with optimized platelet concentration
• State-of-the-art centrifuge and filtration technology for high-yield recovery
• Image-guided precision injections for maximum effectiveness
• Integrated rehab and recovery protocols to support long-term joint health

We don’t believe in “one-size-fits-all medicine”: tailoring every treatment to the individual—ensures patients receive the right dose, right technique, and right approach for their unique conditions and goals.

Is PRP Right for You?
If you’ve been diagnosed with mild to moderate knee osteoarthritis, or if you’re looking for nonsurgical treatments for joint pain, PRP may be a powerful and natural solution to help you stay active and avoid more invasive procedures, such as a total knee replacement.

Schedule a consultation today to learn more about high-dose PRP therapy. Trusted by top athletes, professionals, and patients seeking the most advanced care in orthopedic medicine. The Orthohealing Center offers a full range of regenerative medicine treatments.

📞 Call us or book online to take the next step toward pain-free movement.